Rifampicin Isoniazid Ethambutol- Rcinexe 3mg
Information About Rifampicin Isoniazid Ethambutol- Rcinexe 3mg
About Rifampicin Isoniazid Ethambutol- Rcinexe 3mg
The Medicine Brand RcinexE 3Mg is manufactured by Lupin Laboratories Ltd and mainly contents the generic drug Rifampicin Isoniazid Ethambutol.
Pakaging
60
Active Ingredients For Rifampicin Isoniazid Ethambutol- Rcinexe 3mg
Rifampicin Isoniazid Ethambutol 3Mg
Diseases List For Which Rifampicin Isoniazid Ethambutol- Rcinexe 3mg Is Prescribed
This Drug Is Prescribed For ANTITUBERCULOSIS THERAPY
Other Significations For Rifampicin Isoniazid Ethambutol- Rcinexe 3mg
This Medication ANTITUBERCULOSIS THERAPY FIRSTLINE DRUGS 1 ISONIAZID INH bactericidial unknown but thought to be inhibition of the biosynthesis of mycolic acids Penetrates readily into all body fluids and cells including the CNS similar to concentrations as in plasma Metabolized primarily by the liver as a result of enzymatic acetylation and enzymatic hydrolysis Halflife ranges from 13 hours and dependent on whether the patient is a fast or slow acetylator Doses are not reduced in renal impairment except in advanced renal failure 9 of all clinical isolates of TB resistant to INH a Dosage usually oral can be intramuscular Daily Dose Adults 5 mgkg Maximum dose 300 mg Children 10 to 20 mgkg Maximum dose 300 mg Twice Weekly Adults 15 mgkg Maximum dose 900 mg Children 20 to 40 mgkg Maximum dose 900 mg b Adverse Effects 54 incidence Hepatitis 1 Adverse reaction 1215 or more of patients on INH may have transaminase elevations 1 develop frank hepatitis which can lead to death in rare cases Patients with preexisitng liver disease older patients postpartem and pregnant patients are at risk for the development of hepatitis It is rarely seen in patients under 30 years but is reported in over 2 of patients over 50 years of age There is no increased risk of hepatitis for most patients when isoniazid and rifampin are used together Mild hepatic disease does not preclude the use of INH and rifampin although serial monitoring is suggested Elevations of the SGOT or SGPT to 35 times normal should lead to reassessment of the regimens if baseline SGOT or SGPT is 68 times normal levels INH and rifampin should be avoided Neurological Toxicity less common INH exerts its neurotoxic effect through enhanced elimination of pyridoxine andor competitive inhibition with pyridoxine in its action as a cofactor in the synthesis of synaptic neurotransmitters Peripheral neuropathies 02 most common but rarely seizures optic neuritis encephalopathies and the handshoulder syndrome can occur Concomitant administration of pyridoxine 1050 mg daily The routine prophylactic use of pyridoxine with isoniazid should be considered in patients predisposed to neurologic toxicity because of pregnancy diabetes uremia alcoholism malnutrition or a prior seizure disorder Hypersensitivity Reactions Fever 12 rash 2 and rheumatoid syndromes can occur Positive antinuclear antibodies and lupuserythematous cell preparation my be seen c Drug Interactions Inhibition of metabolism of phenytoin carbamazepine primidone and warfarin 2 RIFAMPIN bactericidal MOA Inhibits DNAdependent RNA polymerase of mycobacteria and other microorganisms leading to suppression of initiation of chain formation in RNA synthesis The oral form is well absorbed from the GI tract in the fasting state Rifampin is well distributed with adequate concentrations in body fluids serum urine saliva pleura including the CSF Rifampin is deacetylated by the liver and its halflife 155 hours is prolonged in hepatic diseases There is no need to adjust doses in renal failure 4 of all TB clinical isolates resistant to RIF a Dosage usually oral can be intravenous Daily Dose Adults 10 mgkg Maximum dose 600 mg Children 10 to 20 mgkg Maximum dose 600 mg Twice Weekly Adults 10 mgkg Maximum dose 600 mg Children 10 to 20 mgkg Maximum dose 600 mg b Adverse Effects 4 Hepatotoxicity 2030 of patients who receive a combination of INHRIF will experience a mildmoderate rise in transaminanses Immunological Reactions Allergic andor hypersensitivity reactions such as drug fever skin rashes and eosinophilia are uncommon A flulike syndrome with fever myalgia and headache can occur Occurs more common with irregular administration vs routine intermittent tuberculosis regimens Redorange Discoloration of the urine saliva sweat and tears and patients should be forewarned of this to prevent unnecessary anxiety soft contact lenses may become permanently discolored Gastrointestinal Epigastric distress nausea and vomiting 15 abdominal cramps diarrhea have occasionally required discontinuation of the drug c Drug Interactions Rifampin is a potent inducer of hepatic drug metabolizing enzymes It can alter the metabolism of AZT protease inhibitors contraceptives oral anticoagulants 3 PYRAZINAMIDE PZA bactericidal MOA Split into ammonia and pyrazinoic acid It is well absorbed orally and penetrates the CNS when the meninges are inflamed he major route of excretion is renal glomerular filtration but the drug is also hydrolyzed and then hydroxylated 6 of all TB clinical isolates resistant to PZA a Dosage oral Daily Dose Adults 15 to 30 mgkg Maximum dose 20 Gm Children 15 to 30 mgkg Maximum dose 20 Gm Twice Weekly Adults 50 to 70 mgkg Children 50 to 70 mgkg b Adverse Effects Hepatotoxicity uncommon Serial liver function tests should be monitored only in highrisk patients or during longterm therapy PZA does not significantly increase the risk of hepatotoxicity when used at a dosage of 15 to 30 mgkgday when added to a regimen of INH and rifampin during the initial 2 months of therapy Hyperuricemia Uncommon Interferes with the excretion of urate by decreasing its tubular secretion Nausea vomiting 4 ETHAMBUTOL bactericidal MOA Inhibit the incorporation of mycolic acid into the mycobacterial cell wall About 7580 of an oral dose is absorbed from the GI tract Penetrates tissue well except the CNS even when the meninges are inflamed About 80 of the dose is excreted unchanged in the urine and 20 passes unchanged in the feces 8 to 15 is excreted in the urine in the form of various metabolites Elimination halflife is 34 hours Doses must be reduced in renal failure 23 of all TB clinical isolates resistant to EMB a Dosage oral Daily Dose Adults 15 to 25 mgkg Maximum dose 25 Gm Children 15 to 25 mgkg Maximum dos
Precautions To Be Taken Before Rifampicin Isoniazid Ethambutol- Rcinexe 3mg
Rifampicin is known to interact with other drugs like Abacavir Aluminium Hydroxide and Oxide Aminophylline Amprenavir ArtesunateAtovaquone Bisoprolol Fumarate Bromazepam Calcifediol CarvedilolCelecoxib Chloramphenicol Chlorpropamide CholecalciferolCiprofloxacin Clofazimine Clofibrate CoTrimoxazole CorticotropinCortisone Acetate Cyclosporin A Dapsone Desogestrel DesonideDexamethasone Diazepam Dienoestrol Digitoxin Digoxin Diltiazem HCl Disopyramide Disulfiram Doxycycline Dydrogesterone Enalapril Maleate Erlotinib Estazolam Estradiol Valerate EstradiolEthinyloestradiol Ethionamide Ethynodiol Diacetate FelodipineFluconazole Fludrocortisone Acetate Flunisolide FluprednisoloneFluticasone Propionate Fosphenytoin Gallopamil GestodeneGestrinone Gliclazide Haloperidol Hexobarbitone Na HydrocortisoneImidapril Isoniazid Itraconazole Ketoconazole Lercanidipine HClLevonorgestrel Lynoestrenol Megestrol Acetate MeprobamateMestranol Methadone Methylprednisolone Mexiletine MontelukastNelfinavir Nevirapine Norethisterone Norgestimate Ondansetron HClOxtriphylline Choline Theophyllinate ParaAmino Salicylic AcidPrajmalium Bitartarate Prednisolone and Prednisone Prednisolone Tebutate Probenecid Progesterone Propafenone HCl ProthionamideQuinidine Quinine Ranolazine Repaglinide Riluzole Ritonavir RofecoxibRosiglitazone Maleate Saquinavir Stilboestrol SulphasalazineSunitinib Tacrolimus Terbinafine HCl Theophylline TiboloneTocainide HCl Trimethoprim Verapamil HCl Warfarin NaZidovudine Zolpidem Tartrate Zopiclone
Major Conditions And Care
Pregnancy And Rifampicin Isoniazid Ethambutol- Rcinexe 3mg
Can We Take Rifampicin Isoniazid Ethambutol- Rcinexe 3mg During Pregnancy?
Pregnancy Class D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans but potential benefits may warrant use of the drug in pregnant women despite potential risks
Lactation And Rifampicin Isoniazid Ethambutol- Rcinexe 3mg
Can We Use Rifampicin Isoniazid Ethambutol- Rcinexe 3mg During Lactation
Lactation Class L4 There is positive evidence of risk to a breastfed infant or to breastmilk production but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant eg if the drug is needed in a lifethreatening situation or for a serious disease for which safer drugs cannot be used or are ineffective
Side Effects Of Rifampicin Isoniazid Ethambutol- Rcinexe 3mg
Nausea stomach upset skin rash acute toxicity
More Danger Effects Fatal Effect Due To Overdose Of Rifampicin Isoniazid Ethambutol- Rcinexe 3mg
Nausea stomach upset skin rash acute toxicity
Rifampicin Isoniazid Ethambutol- Rcinexe 3mg Is Manufactured By , Lupin Laboratories Ltd
Rifampicin Isoniazid Ethambutol- Rcinexe 3mg Contains Mainly The Drug Rifampicin Isoniazid Ethambutol